In this addition to the Medal of Honor franchise, you play as three different characters from previous Medal of Honor games: Lt. James Patterson from the original MOH and MOH: Frontline, Sgt. John Baker from MOH: Allied Assault, and Lt. William Holt from MOH: European Assault, in three different campaigns across Italy, Belgium and Holland. Each campaign consists of different missions that involve capturing or destroying certain objectives.

This World War II-themed shooter features a large amount of unlockable items like new uniforms as well as the ability to complete any mission or campaign on varying difficulty levels. An online multiplayer option allows up to 8 people on Ad Hoc mode or up to 32 people in infrastructure mode. Game modes include Hold the Line, Deathmatch and Capture the Flag.